Researchers Identify Predictors of Suicide in Women

Woman sitting on a swing and covering her faceA combination of questionnaires and blood tests could assess suicide risk in women with psychiatric conditions, according to a study published in Molecular Psychiatry.

According to the American Foundation for Suicide Prevention, suicide is the 10th leading cause of death in the United States, claiming 42,773 lives each year. Men are 3.5 times more likely than women to die by suicide, so research has historically focused on men’s suicidal behavior. However, for every suicide there are 25 attempts, and women have a higher rate of attempted suicide than men.

What Factors Predict Suicide in Women?

Researchers followed 51 women diagnosed with psychiatric conditions that tend to increase the risk of suicide, including depression, schizophrenia, and bipolar. In regular assessments with each participant, researchers asked about suicidal thoughts, noting any instances in which a participant swung between no suicidal thoughts and a high level of suicidal ideation.

They tested 12 participants with these thought swings and found some biomarkers changed between visits with high and low suicidal ideation. They also gathered data from the Marion County Coroner’s Office in Indianapolis on six women who died by suicide. Blood tests from these women revealed 50 biomarkers associated with an increased risk of suicide.

The biomarkers were not necessarily genes for suicide, but rather genes that altered biological functions that increased the risk of suicide. For example, women were more likely to attempt suicide when genes altered their body’s response to lithium and when they faced genetic circadian rhythm disturbances.

Researchers also gathered medical records from a separate group of 33 women with similar psychiatric histories. This control group allowed researchers to test whether the biomarkers increased the risk of psychiatric issues or of suicide. Even in women with similar psychiatric problems, suicide rates were lower if they did not have biomarkers associated with suicide.

The team also used questionnaire apps to measure suicidal thoughts and attempts, stress, mood, and overall health. The apps looked at behavioral, lifestyle, and emotional risk factors for suicide without directly assessing for suicidal thoughts.

Taken in conjunction with the questionnaires, blood-based biomarkers for suicide predicted suicidal thoughts with 82% accuracy, and suicide-related hospitalizations with 78% accuracy.

Could a Blood Test Predict Suicide?

Though the research suggests objective, blood-based measurements could effectively predict suicide risk, the team is cautious about overstating the results. They emphasize that they do not know how effective these biomarkers might be in people without a psychiatric history.

In 2015, the study’s authors published a similar study of suicide predictors in men. That study, too, found blood-based biomarkers and questionnaire responses could predict suicide.


  1. American Foundation for Suicide Prevention. (2014). Suicide Statistics. Retrieved from
  2. Levey, D. F., Niculescu, E. M., Le-Niculescu, H., Dainton, H. L., Phalen, P. L., Ladd, T. B., . . . Niculescu, A. B. (2016). Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry. doi:10.1038/mp.2016.31
  3. Objective predictors of suicidality in women identified. (2016, April 5). Retrieved from

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  • Leave a Comment
  • Nancy


    April 7th, 2016 at 5:12 PM

    There are 25 attempts of suicide for every suicide?
    Wow, that is a pretty eye opening as well as heartbreaking statistic.

  • clarke


    April 8th, 2016 at 7:58 AM

    I wonder why suicide is so much more common in males than it is with females.

  • Roni H

    Roni H

    April 11th, 2016 at 3:56 PM

    My thoughts have always been that women kill themselves even as they are still hoping that there will be someone out there who sees how much pain they are in and can help them get out of what must feel like a drowning. I don’t think that most women do it to hurt someone else, but because they are hurting so much themselves for whatever reasons and that has made living just too unbearable.

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