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Zoloft (Sertraline)

What is Zoloft? Zoloft (sertraline) is part of a group of medications called selective serotonin-reuptake inhibitors (SSRIs). Zoloft is used to control the symptoms that accompany depression, anxiety, or panic attacks in adults, young adults, and teens. Zoloft is also used to control obsessive compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) symptoms. Zoloft comes in both tablet and concentrated liquid form and is usually taken once per day. The liquid version of Zoloft is a concentrate that must be added to water, ginger ale, orange juice, lemon lime soda, or lemonade. It may take several weeks on Zoloft before a person begins to feel the full effect of this medication, and it is important to continue taking Zoloft as prescribed even when one feels well.


Important Information Before Use:

  • Zoloft can help control the behavior that accompanies your condition, but it won't cure it.
  • If you have or have ever had a heart attack, heart disease, seizures, or liver disease, you should discuss this with your doctor before taking Zoloft.
  • You should also mention any serious reactions you have had to other similar medications.
  • Talk to your doctor about Zoloft and alcohol use if you use alcohol regularly.
  • Zoloft may interact with other medications or supplements, including Antabuse (disulfiram), antihistamines, anticoagulants, antidepressants, antifungals, sleeping pills, St. John's Wort, pain relievers, high blood pressure medications, migraine medications, and more. If you are taking any other prescription drugs or supplements, you should check with your doctor or pharmacist before taking Zoloft.

Important Information During Use:

  • If you are pregnant or become pregnant while taking Zoloft, you should talk to your doctor about alternative treatments for your condition. Zoloft can cause problems in newborns if taken during pregnancy or while breastfeeding.
  • Zoloft can make you extremely drowsy; using alcohol with Zoloft can worsen this side effect.
  • Zoloft overdose can be fatal, and symptoms include vomiting, dizziness, seizures, irregular heartbeat, high blood pressure, hallucinations, breathing difficulties, fainting, and coma.
  • If you experience serious or severe side effects from Zoloft, you should call your doctor immediately.


Zoloft Side Effects


  • Blurred vision
  • Seizures
  • Hallucinations
  • Irregular or fast heartbeat
  • Abnormal bleeding, bruising, or blistering
  • Muscle stiffness
  • Fever or sweating

Less Serious:

  • Drowsiness or dizziness
  • Sweating
  • Dry mouth
  • Changes in appetite or weight
  • Restlessness, nervousness, or agitation
  • Stomach upset, gas, vomiting, diarrhea, or constipation
  • Headache
  • Pain or tingling in feet or hands
  • Change in sex drive or ability
  • Uncontrollable tremors or shaking
  • Sore throat

Do not stop taking Zoloft abruptly; see your doctor before reducing or discontinuing this medication. You can reduce the symptoms you feel during withdrawal by slowly tapering off of this medication.

Possible Symptoms of Zoloft Withdrawal:

  • Insomnia
  • Agitation, anxiety, or irritability
  • Headache
  • Confusion
  • Tiredness or dizziness


Comparing Zoloft

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Last Update: 06-29-2012


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