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Tranxene (Clorazepate)

Tranxene, also called clorazepate, is part of a group of medications called benzodiazepines and is used to relieve anxiety and to ease the symptoms of alcohol withdrawal. It can help control your symptoms, but it will not cure your condition. This drug can also be prescribed to reduce the frequency or intensity of some types of seizures.


Tranxene comes in tablet form and is usually taken one to three times per day. It is important to take this medication exactly as prescribed. The dosage prescribed by a doctor will depend on the reason the drug is being used. If this medication is being used to control anxiety, a doctor will start their patient on a low dose and gradually increase the amount taken over time. For alcohol withdrawal, a person will likely be started on a high dose and then tapered off of this medication over time.

Important Information Before Use

  • Tranxene can be habit forming and should be taken only as directed.
  • If you have or have ever had glaucoma, depression, or kidney or liver disease, you should talk to your doctor about these conditions before you take Tranxene.
  • If you currently use or have ever used street drugs or have overused any prescription medications, talk to your doctor before you start taking this prescription.
  • If you are over age sixty-five, you should not use this drug; work with your doctor to find a different medication to treat your condition.
  • If you smoke or use tobacco products, you should talk to your doctor before using this drug; smoking may reduce the effectiveness of this medication.
  • Tranxene may interact with other medications or supplements, including antihistamines, antidepressants, herbal remedies and vitamins, sleeping pills, oral contraceptives, tranquilizers, and more. If you are taking any other prescription drugs or supplements, you should check with your doctor or pharmacist before taking this medication.

Important Information During Use

  • Medications like Tranxene can cause suicidal thoughts and actions in some children, teens, and young adults. Monitor yourself or your child carefully for extreme behaviors and personality changes.
  • This medication is not recommended for use during pregnancy. Let your doctor know right away if you are pregnant or become pregnant while taking this medication.
  • This drug can make you extremely drowsy; use care when driving or operating heavy equipment, and avoid using alcohol with this medication. Using alcohol can increase this side effect.
  • Tell your doctor, dentist, or surgeon that you are taking this drug before you have any type of surgery, including dental surgery.
  • Symptoms of overdose include extreme drowsiness, slowed reflexes, loss of coordination, fainting, or coma. Overdose is a medical emergency and should be treated right away.

Side Effects

If you experience serious or severe side effects from Tranxene, you should call your doctor immediately. Serious side effects may include:

  • Skin rash
  • Tremors, shaking, or the inability to sit still
  • Slurred speech or speech difficulties
  • Blurry or double vision
  • Difficulty walking or keeping your balance

Less serious side effects include:

  • Drowsiness or dizziness
  • Dry mouth
  • Headache
  • Confusion


You should not stop taking Tranxene abruptly. Your doctor can help you reduce the symptoms you feel during withdrawal by slowly tapering off over time. Talk to your doctor before reducing or discontinuing this medication. Possible symptoms of withdrawal include:

  • Insomnia or sleep difficulties
  • Irritability or nervousness
  • Memory problems or confusion
  • Shaking or tremors
  • Stomach pains, vomiting, or diarrhea
  • Increased anxiety or return of anxiety symptoms


  1. Tranxene T-Tab. (n.d.). Retrieved from http://www.webmd.com/drugs/2/drug-14016/tranxene-t-tab-oral/details#
  2. Tranxene T-Tab. (2014, December 3). Retrieved from http://www.drugs.com/cdi/tranxene-t-tab.html

Page content reviewed by James Pendleton, ND


Last Update: 12-22-2014


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