Wellbutrin, also known by the trade name bupropion, is an antidepressant medication. The XL version is an extended-release formula and is usually taken once daily. This prescription is often used to treat seasonal affective disorder, a form of depression occurring during the fall and winter months. It is also a standard treatment for major depression in adults. Zyban, a low-dose form of bupropion, has demonstrated effectiveness for smoking cessation and it has been licensed in the United States and the United Kingdom for this purpose.
Doctors typically start people on low doses of the medication and increase it until the ideal dosage is achieved. The full effects of the medication may not be felt for up to four weeks. When stopping the medication, doctors may tell people to taper doses downward for two weeks before complete termination.
Before use, talk with your doctor about your medical history. Your doctor will need to know if you have ever had a heart attack, had high blood pressure, diabetes, heart disease, or substance abuse problems. Alcohol can increase the side effects of Wellbutrin, particularly drowsiness.
Tell your doctor about all of your medication allergies. Additionally, tell your doctor and pharmacist which prescription and nonprescription drugs you currently take. Even herbal products like St. John's Wort can lead to unwanted drug interactions. Wellbutrin, like many antidepressants, can have a dangerous interaction with a class of drugs called monoamine oxidase inhibitors (MAOIs). If you currently take a MAOI or have stopped taking one within the last two weeks, your doctor will likely not prescribe Wellbutrin. Examples of these drugs include Marplan (isocarboxazid), Nardil (phenelzine), and Emsam (selegiline).
Wellbutrin is not approved for use in people younger than 18.
Rare, adverse psychiatric side effects of this medication may include anger, paranoia, hallucinations, and hostility. Other serious effects may include:
Less serious side effects of this drug can include:
Withdrawal from Wellbutrin is usually not considered dangerous. Gradual tapering of the dose minimizes any withdrawal effects while allowing faster reinstatement of the medication should symptoms of depression return. Possible symptoms of withdrawal may include:
Page content reviewed by James Pendleton, ND
Last Update: 02-11-2015