The way a person’s brain reacts to inequity..." /> The way a person’s brain reacts to inequity..." />

Study: Empathy for Unfairness Linked to Depression

A stack of cash and a stack of pennies on opposite sides of a scale.The way a person’s brain reacts to inequity may correlate with the risk of later depression, according to a study published in Nature Human Behavior. The study used a video game with high levels of unfairness to link prosocial attitudes to an increased risk of depression.

According to the study, some research suggests that increases in economic inequality are associated with an increase in depression rates.

Prosocial Attitudes, Inequality, and Depression

For the study, researchers asked 343 participants to play a video game. Before the game, they assessed each participant’s social value orientation, a measure of the person’s views about economic inequity.

Social value orientation falls into three categories:

  • Individualists want to maximize their own income regardless of the effect this has on others.
  • Prosocials prefer to distribute resources in a way that minimizes inequity.
  • Competitors, the smallest segment of the population, want to compete with and feel superior to others.

Participants also completed measures of depression, including the Beck Depression Inventory.

Investigators hooked participants up to a functional magnetic resonance imaging (fMRI) machine. An fMRI machine measures blood flow to the brain during the performance of specific tasks, potentially revealing information about how the brain processes the task. Previous research has revealed those who are prosocial show more activity in the amygdala in response to perceived inequality.

While attached to the fMRI machine, participants played a game dubbed the ultimatum game. The game, which is designed to recreate economic inequality, presents participants with offers that either maximize or minimize inequality. During the game, some participants showed more activity in the amygdala and hippocampus. These brain regions are associated with processing emotion, and some research suggests they are smaller in people with depression.

A year later, researchers again assessed participants’ depression levels. Those who had demonstrated higher activity levels in the amygdala and hippocampus during the game were more likely to be experiencing depression.

Is There a Link Between Empathy and Depression?

The game is one way to measure empathy, as it assesses how a person reacts to perceived unfairness. More brain activity in the amygdala and hippocampus during the game suggests a stronger reaction to inequity. This, the authors of the study believe, may mean people are more likely to become depressed when they hold prosocial values that induce a strong reaction to inequity.

This association between prosocial attitudes and depression persisted even when researchers controlled for income and other demographic factors that correlate with depression risk.


Tanaka, T., Yamamoto, T., & Haruno, M. (2017). Brain response patterns to economic inequity predict present and future depression indices. Nature Human Behaviour, 1(10), 748-756. doi:10.1038/s41562-017-0207-1

© Copyright 2017 All rights reserved.

The preceding article was solely written by the author named above. Any views and opinions expressed are not necessarily shared by Questions or concerns about the preceding article can be directed to the author or posted as a comment below.

  • Leave a Comment
  • Rena

    October 16th, 2017 at 11:09 AM

    Interesting but not really all that practical for diagnosis purposes.

  • Julian

    October 25th, 2017 at 12:31 PM

    So we should instead just be immune to the suffering of others?

Leave a Comment

By commenting you acknowledge acceptance of's Terms and Conditions of Use.

* Indicates required field.

GoodTherapy uses cookies to personalize content and ads to provide better services for our users and to analyze our traffic. By continuing to use this site you consent to our cookies.