Dopamine is one of several neurotransmitters strongly linked with mood and sensations of pleasure. Neurotransmitters are chemicals that carry signals between neurons.
What Is Dopamine?
Many people are aware of dopamine for its role in regulating motivation and reward-driven behavior. Larger amounts of dopamine make people feel good, and this good feeling motivates people to repeat the behavior that triggered the good feeling. In this way, dopamine is an important part of survival. Behaviors that increase likelihood of survival, such as eating calorie-dense foods, are reinforced with the help of dopamine.
Where Is Dopamine Produced?
Dopamine belongs to the catecholamine family of neurotransmitters. Catecholamines are part of the body’s fight or flight response. Epinephrine, or adrenaline, and norepinephrine, or noradrenaline, are the other two catecholamine neurotransmitters. These neurotransmitters are produced in the brain, brainstem, and adrenal glands; and more specifically, dopamine is released from a strip of brain tissue called the substantia nigra. When released, neurotransmitters function as hormones in the body.
Dopamine is metabolized from tyrosine and phenylalanine. Neurons that use dopamine as their primary neurotransmitter exist mostly in the midbrain, which plays a large role in controlling motor function and managing sensory input, among other things.
When Is Dopamine Released?
Dopamine is released during situations in which people experience pleasure. The release of dopamine helps reinforce the pleasurable behavior, increasing the likelihood the individual will repeat that behavior to get the same feeling.
Activities that stimulate the release of dopamine function as survival or coping strategies. The more times they are repeated, the more they may become reinforced. Behaviors and substances that may cause the release of dopamine include:
- Recreational drugs
- Listening to music
Dopamine plays an important role in physical and behavioral health. But while it can help reinforce behaviors that promote long-term health, such as physical activity and getting enough sleep, it can also help reinforce behaviors that are harmful to an individual’s health, from eating too much junk food to opioid misuse and addiction.
What Does Dopamine Do?
Dopamine is implicated in feelings of pleasure and plays a prominent role in addiction. People with substance dependencies may grow dependent partially because of the activation of dopamine. Some other ways dopamine affects the body include:
- Mood regulation: Insufficient dopamine can contribute to depression. Meanwhile, some research has found that too much dopamine could cause mania.
- Slows the production of prolactin: Prolactin is involved in both lactation and sexual gratification.
- Regulates sleep: Dopamine helps inhibit the production of melatonin toward the end of a night’s sleep, contributing to wakefulness.
- Regulates attention and memory: Many studies have demonstrated dopamine’s link to attention, memory, and cognition. Disruptions in dopamine have been connected to attention-deficit hyperactivity (ADHD) and schizophrenia, for example.
- Increases goal-oriented behavior: In addition to promoting reward and goal-driven behavior, dopamine may decrease inhibition.
Irregular dopamine levels can cause a variety of psychological problems. For instance, Parkinson’s disease is caused partially by the death of dopamine-secreting neurons. Drugs that increase dopamine production may help people with Parkinson’s, particularly during the early stages of the disease.
How to Increase Dopamine
There are a wide variety of activities that boost dopamine levels in the brain, but not all of them contribute to long-term health. Taking part in behaviors that increase dopamine while improving your health can contribute to the formation of good habits and boost your mood. Some ways to get a natural increase in dopamine include:
- Consume probiotics: Whether taken in supplement form or by eating probiotic rich foods such as yogurt and fermented foods, probiotics have been shown to support dopamine production.
- Sleep: Getting enough sleep each night is one of the best ways to keep your dopamine at a healthy level. One night without sleep has actually been shown to increase dopamine in the short-term. However, the increase in dopamine caused by long-term sleep deprivation could cause dopamine receptors to become less sensitive to dopamine, making it difficult for a person to feel awake.
- Spend time in the sun: Sunlight facilitates the body’s production of vitamin D. Vitamin D, in turn, can help increase dopamine production.
- Exercise: In addition to endorphins, exercise can increase dopamine levels, contributing to the mood improvement that often comes with physical activity.
- Listen to music: Multiple studies have shown that listening to music you like causes dopamine to be released in the brain.
- Avoid sugary foods and junk food: Eating foods that release large amounts of dopamine (which are often high in sugar and fat) can have a desensitizing effect over time. Sticking to whole foods ensures the body’s dopamine receptors don’t become overpowered, thereby creating the need for foods that stimulate the release of more dopamine.
Dopamine and Addiction
Dopamine is well-known for the role it plays in addiction. As it plays a key role in helping develop habits that support health and survival, so can it support the formation of self-destructive coping mechanisms.
Whether the addiction is to sugary food, sex, alcohol, or drugs, the role dopamine plays is the same. Addictive substances overload the brain with dopamine, causing dopamine receptors to become less sensitive to it. Higher and higher amounts of dopamine are then required in order to get the same initial feeling caused by the addictive substance. When the addictive substance is not delivered in higher amounts or withheld completely, withdrawal symptoms may appear.
Researchers have found that dopamine plays a similar role in many compulsive behaviors, such as compulsive pornography use, internet addiction, and compulsive gambling. These behaviors stimulate a similar rush of dopamine to the brain, establishing it as rewarding and reinforcing it as a habit. Individuals with these compulsions may feel as though they have lost control over that aspect of their behavior.
Dopamine and Mental Health
Dopamine also has significant function in some mental health conditions. A few of these include:
- Schizophrenia: Dopamine dysregulation has been found to be present in the brains of individuals with schizophrenia. It may be at least partly responsible for both positive and negative symptoms of schizophrenia, including hallucinations and delusions as well as a lack of pleasure and motivation.
- Depression: While depression is classically associated more often with serotonin dysregulation, some research supports the idea that dopamine could also be associated with the loss of pleasure, or anhedonia, associated with depression.
- ADHD: Dopamine is thought to be a key factor in the development of ADHD. Studies have shown that lower than usual amounts of dopamine in the brain are often present alongside symptoms of ADHD.
- Anxiety: One study linked anxiety to insufficient dopamine in the amygdala. Since the amygdala is implicated in the fight or flight response, dopamine could act as a way to quiet the amygdala when it reacts to a “false alarm.” Without enough dopamine to stop the fight or flight response, higher levels of anxiety could be the result.
Research exploring the many links between dopamine and mental health is ongoing, and experts are still discovering all the ways dopamine is connected to behavioral health.
What If I Have Too Little or Too Much Dopamine?
Dopamine dysregulation could mean that the brain is producing too little or too much dopamine. Low dopamine, or dopamine deficiency, can be caused by a variety of factors, including conditions such as Parkinson’s disease, schizophrenia, and depression. Drug and sugar addiction have also been found to cause dopamine deficiency over time. Some low dopamine symptoms include fatigue, moodiness, dysphoria, physical pain, and changes in weight, sex drive, and ability to focus. As many other conditions share these symptoms, it’s important to consult your health care provider if you’re experiencing these symptoms.
It’s also possible to have too much dopamine. Effects of overly high dopamine levels include high libido, anxiety, difficulty sleeping, increased energy, mania, stress, and improved ability to focus and learn, among others. When certain parts of the brain are exposed to too much dopamine, for instance right after an individual takes illicit drugs, other behaviors may be present. These can include aggression, hallucinations, twitching, nausea and/or vomiting, and depression.
Dopamine and Psychoactive Drugs
Because dopamine contributes to feelings of pleasure, a rush of dopamine can cause an immediate change in mood. Dopamine-producing drugs such as Adderall and Dexadrine are sometimes prescribed to people experiencing treatment-resistant depression. Medications that increase dopamine production can be highly addictive, and thus are not recommended for people with substance abuse problems. Some dopamine-producing drugs can also cause cardiovascular and renal problems, and people prescribed amphetamines and related drugs should be carefully monitored by a physician.
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Last Updated: 09-24-2019
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boniphaceApril 11th, 2020 at 10:47 PM
DonnaMay 22nd, 2020 at 5:11 AM
I have too much dopamine but I m not seeing any medications you can use for that.
You have listed medication for having less dopamine.
Is there any for having too much? I was in a vehicular accident and this is the result.
MattSeptember 9th, 2020 at 5:58 PM
Antipsychotics are generally used to lower dopamine. Normally these are used for controlling hallucinations, paranoia, and delusions in schizophrenia or bipolar.
ScottOctober 1st, 2020 at 10:38 PM
Donna,were you injured in the car wreck and prescribed Opiates for the pain and that’s why your dopamine levels are ready high?…Or did it just happen after the wreck with no reasoning?
N. ChhabraFebruary 2nd, 2021 at 3:22 AM
I have seen a similar vehicular example Donna. Kindly request the blogger to mention on more of treatment on Pro-dopamine people.
PAULFebruary 2nd, 2021 at 4:09 AM
Very insightful. Thanks!
CindyApril 22nd, 2021 at 4:47 PM
I suffer from worry depression I worry about everything I have a fear of everything and I want something that will help me because doctors refuse to see my concerns and
AhmedAugust 8th, 2021 at 9:38 AM
Melatonine increase at night dopamine decrease Melatonine i had anight free of sleep trying drugs to lower dopamine psychotically What gappeneed%?
AhmedAugust 8th, 2021 at 9:40 AM
Dealing with psychotic drugs had anight free of sleep What happened to nelatonine
mercedesAugust 25th, 2021 at 5:06 AM
I was mis-diagnosed as schiz. and I think it was too much dopamine. The anti-psych meds made me ill with Cyclic Vomiting Syndrome from which I suffered for ten years and almost died several times. I finally threw all the pills out, stopped puking, and got my life back. I now see a Dr. of FUNCTIONAL Medicine and I take supplements to get my neurotransmitters working correctly. After losing ten years, I finally have a life again.
EmersonAugust 27th, 2021 at 11:21 PM
Are you able to recommend and identify the doctor that treated you? Thanks
ArtOctober 3rd, 2021 at 7:07 AM
How to increase endorphins and dopamine through activating a little-known brain circuit, as demonstrated by some positive thinking.
(and dopamine does NOT cause pleasure, but can stimulate opioid systems that do!)
Persistent positive or meaningful thinking in a resting state will increase pleasure and arousal, and avoid negative ideation that elicits opposing emotional states.
Any relaxation protocol from eyes closed rest to mindfulness is pleasurable, due to the release of endogenous opioids (endorphins). If concurrent persistent positive or meaningful ideation occurs (meaning is defined as thinking of or doing actions that have branching novel positive implications), this induces a feeling of arousal as mediated by dopamine systems. Dopamine and opioid systems are synergistic, or when activated simultaneously reciprocally stimulate each other, causing feelings of greater pleasure and arousal, or ecstatic states. This explains why ‘loving kindness’ and positive meditation, savoring, peak, or flow experiences that have rest as an entailment ‘feel’ different from resting states, yet nonetheless represent unremarkable and simple neural processes that can be explained and replicated with ease by anyone.
A formal explanation from a neurologically based learning theory of this technique is provided on pp. 44-52 in a little open-source book on the psychology of rest linked below. (The flow experience is discussed on pp. 81-86.)
The Psychology of Rest, from the International Journal of Stress Management, by this author
More on the Neuroscience of Pleasure
Berridge Lab, University of Michigan
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