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Loxitane (Loxapine)

Loxitane (loxapine) is available by prescription only and is used to control strong emotions, unwanted thoughts, actions, and apathy that can accompany schizophrenia. This prescription can provide relief from the symptoms of schizophrenia, but it will not cure the condition. This drug is considered a conventional antipsychotic medication and helps control disturbing or abnormal thoughts and emotions.


Most people start out taking a low dose of Loxitane prescribed by their psychiatrist or doctor. This medication must be prescribed by a doctor. After the first week on this medication, a doctor may increase the amount of Loxitane a person takes each day to achieve the desired level of relief. This drug is sold in capsule form and is usually taken two to four times per day. You will not get an immediate result when you take this medication. It may take a few weeks to feel the full effects from this medication.

Important Information Before Use

Older adults with signs of dementia should not take Loxitane. If you suffer from or have ever been diagnosed with glaucoma, breast cancer, or heart disease, you should talk to your doctor before you start taking this drug. You should also mention current or past difficulty urinating and any serious reactions you have had to other similar medications. This medication may interact with other medications, so check with your doctor or pharmacist if you are taking other prescription drugs or supplements.

Important Information During Use

  • Loxitane can cause problems in newborns if taken during pregnancy. If you are pregnant or become pregnant while taking Loxitane, you should talk to your doctor about alternative treatments for your condition.
  • The correct amount of Loxitane will vary by individual, so you should only take the amount of Loxitane that is right for you. Take Loxitane on schedule every day, whether you feel like you need it or not.
  • Your surgeon or anesthesiologist needs to know that you are taking Loxitane if you are having any type of surgery, including oral or dental surgery.
  • Overdose symptoms for this drug include dizziness, loss of consciousness, kidney failure, seizures, and difficulty breathing.

Side Effects

If you experience serious or severe side effects from Loxitane, you should call your doctor. Alcoholic beverages can increase the amount or severity of side effects from this drug. Serious side effects can include:

  • Confusion
  • Seizures
  • Irregular or fast heartbeat
  • Sweating
  • Tightness in throat or neck; difficulty swallowing or breathing
  • Mouth or tongue problems, including uncontrollable movements of the mouth, face, or jaw, a tongue that protrudes from the mouth, or unusual tongue movements
  • Vision problems, particularly in low or dim lighting
  • Neck cramps
  • Fever, sweating, or muscle stiffness

Less Serious side effects may include:

  • Drowsiness, dizziness, blurred vision, faintness, or weakness
  • Problems with sleeping, including falling to sleep and staying asleep
  • Weight gain or loss
  • Stomach and digestive system upset, including constipation, nausea, and vomiting
  • Dry mouth, increased saliva or extreme thirst
  • Restlessness or agitation
  • Drooping eyelids, slurred speech, blank facial expression or shuffling walk
  • Hair loss, rash, or itching
  • Tingling or numbness in hands or feet
  • Women may experience breast enlargement, breast milk production, and missed menstrual periods
  • Decreased sexual ability in men
  • Difficulty urinating


The best way to stop taking Loxitane is to slowly reduce your dose over time. By slowly reducing the amount of the drug you take each day, you can reduce the severity of any withdrawal symptoms you experience. Possible symptoms of withdrawal include:

  • Stomach upset or diarrhea
  • Shakiness or dizziness
  • Delusions, hallucinations, and other psychotic symptoms


  1. Loxapine. (2011, May 5). Retrieved from http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682311.html
  2. Loxapine (oral route). (2014, September 1). Retrieved from http://www.mayoclinic.org/drugs-supplements/loxapine-oral-route/description/drg-20064610


Last Update: 12-22-2014


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